Zyprexa & Pre-existing Diabetes
[Home] [Bipolar News] [Bipolar Disorder] [Medications] [Treatments] [Bipolar Disorder/Job/School] [Disabilities] [Ask the Doctor] [Ask David] [Self-Injury] [Personal Stories] [Graham's Column] [Steven's Column] [Storm's Column] [Columnist Archives] [Suicide] [Community Support] [Family Members] [Expressions] [Greeting Cards] [Books] [Awards] [Links & Rings] [About Us] [Contact Us]


Q:  Zyprexa & Pre-existing Diabetes

I read about the concerns with Zyprexa and developing diabetes - but, what if you are already a type 1 diabetic.  Are there any concerns with Zyprexa that need to be monitored then?

Dear Alison
I've not seen a study on this yet, but I can tell you that several of my patients' glucose control seemed to have worsened when they were on, improved when they were off, and worsened again when they went off again. But that's only about 3 patients to go by. Digging around a bit via Google I found a Canadian report from 2001, when the problem was first being recognized. It noted that "Of the 35 reports in which disorders of hyperglycemia were denoted, there were 4 cases of pre-existing diabetes". In other words, these 4 people apparently had enough worsening of their diabetes to get reported to Health Canada. "Exacerbation of pre-existing diabetes" is also reported in a summary from 2003.  

On the basis of this very brief search and my experience, I'd say the answer to your question is yes, monitoring for worsening glucose control is warranted when an atypical anipsychotic such as Zyprexa is started (and probably when it is stopped, watching for hypoglycemia so that the medication approach can be adjusted accordingly). Patients will need to be watchful for this interaction as busy psychiatrists may overlook it. 

Dr. Phelps

Published March, 2006


Bipolar World   1998, 1999, 2000, 2001, 2002, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014
Allie Bloom, David Schafer, M.Ed. (Blackdog)
Partners:  John Haeckel, Judith (Duff) 
Founder:  Colleen Sullivan

Email Us at Bipolar World


About Us  Add a Link  Advance Directives  Alternative Treatments  Ask the Doctor   Ask Dr. Plyler about Bipolar Disorder   Ask The Doctor/ Topic Archives  Awards  Benny the Bipolar Puppy  Bipolar Chat  Bipolar Children  Bipolar Disorder News  Bipolar Help Contract  Bipolar World Forums  Book Reviews  Bookstore  BP & Other mental Illness   Clinical Research Trials & FDA Drug Approval   Community Support   Contact Us  The Continuum of Mania and Depression   Coping   Criteria    Criteria and Diagnosis  Criteria-World Health Disabilities,  DSMV-IV   Dual Diagnosis  eGroups  Expressions (Poetry, Inspiration, Humor, Art Gallery, Memorials  Family Members   Getting Help for a Loved One who Refuses Treatment  Greeting Cards  History of Mental Illness  Indigo  Job and School  Links  Manage Your Medications  Medications   Medication and Weight Gain    News of the Day  Parent Chat  Pay for Meds  Personal Stories  Self Help  Self Injury  Significant Others  Stigma and Mental Health Law  Storm's Column  Suicide!!!  The Suicide Wall  Table of Contents   Treatments  Treatment Compliance  US Disability  Veteran's Chat  What's New?