Q: Lithium Orotate (LiOr) - December 2005|
I really appreciate your open mind in considering the merits of lithium orotate,
as per your
response to "Mr. G." As one of the many
people taking the orotate, I can answer the question you asked Mr. G. Even
taking 960 mg daily (8 tablets), a huge dose by LiOr standards (as much lithium
as there is in 219 mg of lithium carbonate), my serum level repeatedly comes
back as "<0.1". Indeed, a proponent of LiOr for about 30 years,
Jonathan Wright, states that "after a year or so, I quit asking for the
lithium level blood tests, since 100 percent of them came back very low." The
key here is not the serum level, but rather precisely where the lithium
ends up. Relatively very small amounts of lithium are actually needed at the
active site(s) within cell systems, and they can get there using a "mineral
transporter" such as orotate.
As you know the side effects of lithium
carbonate are due to overloading the serum, in order to transport a tiny
fraction of lithium to where it is needed. Lithium orotate gets around this
problem. In fact, I have had no side effects whatsoever with orotate,
even though I couldn't tolerate a rather similar lithium dose as the carbonate
(300 mg). The latter turned me into a lethargic zombie, sort of magnified my
symptoms of depression. Same at 600 mg. So I gave up and later chose to try
LiOr. (Not much luck for me there either, but at least I can tolerate some form
Whether or not LiOr actually works
and is safe are two questions without
clear answers. I share your skepticism and wish someone would do further
Dear Readers --
In his letter here,
has been very gracious and respectful -- despite my ignorance, at first,
regarding this lithium orotate stuff (LiOr). He has taken it upon himself to
educate me, including providing all the references one could ask for, regarding
the history of research on this compound. In fact, he's put that entire
education into a very well-organized website about LiOr to which I'll refer you
in a moment.
The best thing about Dr. Federer
is his desire to know -- not just to gather data that might support LiOr use,
but rather to find out the truth, as best we can determine, about its safety.
He credits me with an open mind, but his is the example to follow. His
attempts to understand the existing research have been extremely detailed and
thorough (he even had my ever-helpful librarian, Hope L., dig up the decades-old
original of the German patent on the compound!).
Not only that.
He's masterminded a web-based research effort in which you might be able to
participate, if you've ever taken LiOr yourself (if not, but you know someone
who has, please pass this news along to them). This simple question he's
mentioning above might just be "answerable", at least in a preliminary way,
using a simple questionnaire he's put together, which can be completed online.
(I've suggested he take up a next career as a web designer for researchers).
Thus this letter is really just a
way to introduce you to Dr.
Federer's website and his
questionnaire (with which I'm quite familiar as I helped with some of the
writing there; he
is very good at generating
enthusiasm and roping in participants!). If you have any interest in LiOr --
and perhaps you should, as he is pretty convinced there might be a better way
to take lithium out there just waiting for us to study -- then you should
take a look at the
website for this lithium orotate research project.
You'll learn a bunch, at minimum. And if this works as hoped, so will we all.
Published December, 2005