Could This be From Seroquel?
[Home] [Bipolar News] [Bipolar Disorder] [Medications] [Treatments] [Bipolar Disorder/Job/School] [Disabilities] [Ask the Doctor] [Ask David] [Self-Injury] [Personal Stories] [Graham's Column] [Steven's Column] [Storm's Column] [Columnist Archives] [Suicide] [Community Support] [Family Members] [Expressions] [Greeting Cards] [Books] [Awards] [Links & Rings] [About Us] [Contact Us]


Q:  Could This be From Seroquel?

My brother was on Seroquel, 100mg only at night (not bid) for 7 months with no titration on or off the drug. Now he has numerous side effects for the last 6 months even though he has been off the drug for 6 months. These include slow beard growth, hair loss, beard turned grey, slow toenail growth, weight loss, no appetite, trouble sleeping, stools turned to clay color, constipation. He is concerned he may have permanent brain damage, and symptoms are getting worse.  An EEG showed low brain wave activity which possibly indicated brain pathology.  Have you heard of this before with any neuroleptics?

Dear Mr. H' -- 
That is not sounding like anything I've ever seen or heard of.  Except for the weight loss, it almost sounds like something hypothyroidism could do.  Of course depression can do quite a few of those things itself.  The "clay-colored stool" invokes problems with the liver or gall bladder system, usually (e.g here's a
basic reference on that). 

At such a low dose, as you point out, it would be extremely unusual, I would think, for Seroquel to have done this.  There is an association between Seroquel and liver problems, perhaps that is a connection worth pursuing.  Your brother has probably had the simple blood test that should show liver problems ("chemistry panel") and the simple test for thyroid problems ("TSH": thyroid stimulating hormone level) so you'd probably want to know that these were okay ("I'm sure you've already checked his thyroid and liver and those blood tests looked okay?").  

Dr. Phelps

Published January, 2003


Bipolar World   1998, 1999, 2000, 2001, 2002, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014
Allie Bloom, David Schafer, M.Ed. (Blackdog)
Partners:  John Haeckel, Judith (Duff) 
Founder:  Colleen Sullivan

Email Us at Bipolar World


About Us  Add a Link  Advance Directives  Alternative Treatments  Ask the Doctor   Ask Dr. Plyler about Bipolar Disorder   Ask The Doctor/ Topic Archives  Awards  Benny the Bipolar Puppy  Bipolar Chat  Bipolar Children  Bipolar Disorder News  Bipolar Help Contract  Bipolar World Forums  Book Reviews  Bookstore  BP & Other mental Illness   Clinical Research Trials & FDA Drug Approval   Community Support   Contact Us  The Continuum of Mania and Depression   Coping   Criteria    Criteria and Diagnosis  Criteria-World Health Disabilities,  DSMV-IV   Dual Diagnosis  eGroups  Expressions (Poetry, Inspiration, Humor, Art Gallery, Memorials  Family Members   Getting Help for a Loved One who Refuses Treatment  Greeting Cards  History of Mental Illness  Indigo  Job and School  Links  Manage Your Medications  Medications   Medication and Weight Gain    News of the Day  Parent Chat  Pay for Meds  Personal Stories  Self Help  Self Injury  Significant Others  Stigma and Mental Health Law  Storm's Column  Suicide!!!  The Suicide Wall  Table of Contents   Treatments  Treatment Compliance  US Disability  Veteran's Chat  What's New?