Abilify : Depakote & Metabolism
[Home] [Bipolar News] [Bipolar Disorder] [Medications] [Treatments] [Bipolar Disorder/Job/School] [Disabilities] [Ask the Doctor] [Ask David] [Self-Injury] [Personal Stories] [Graham's Column] [Steven's Column] [Storm's Column] [Columnist Archives] [Suicide] [Community Support] [Family Members] [Expressions] [Greeting Cards] [Books] [Awards] [Links & Rings] [About Us] [Contact Us]


Q:  Abilify : Depakote & Metabolism

At 48, over 6' and with only 1500 calories a day with daily exercise, I have gained over 15 pounds since starting Depakote three months ago.  Two questions: does this drug actually change my body's metabolism?  And any experience yet with Abilifx?  Thanks. 

Dear Mr. R' -- 
There is a bit of evidence implicating Depakote in a metabolic shift.  Several research teams are pretty convinced Depakote causes
polycystic ovarian syndrome, which you'll see is a variant of metabolic syndrome, which is clearly associated with weight gain and is by definition a "change in your body's metabolism". 

As for Abilify, my general policy is to let other people find out what the real problems are, as opposed to those which emerged prior to marketing in the FDA-required trials.  For example, it's really only just now becoming clear that Zyprexa can cause really serious weight gain, like but probably worse than Depakote, even to the point of causing diabetes and at least one clear death due to hyperglycemia (you'll see that case cited in the essay on weight gain and bipolar as well as linked from the other links above).  So I don't try new stuff unless I'm forced into it by the failure of older stuff, which doesn't happen too often, so I'm slow to learn -- though I watch the experience of others pretty closely.  Haven't seen anything to distinguish Abilify yet, good or bad. 

Dr. Phelps

Published January, 2003


Bipolar World   1998, 1999, 2000, 2001, 2002, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014
Allie Bloom, David Schafer, M.Ed. (Blackdog)
Partners:  John Haeckel, Judith (Duff) 
Founder:  Colleen Sullivan

Email Us at Bipolar World


About Us  Add a Link  Advance Directives  Alternative Treatments  Ask the Doctor   Ask Dr. Plyler about Bipolar Disorder   Ask The Doctor/ Topic Archives  Awards  Benny the Bipolar Puppy  Bipolar Chat  Bipolar Children  Bipolar Disorder News  Bipolar Help Contract  Bipolar World Forums  Book Reviews  Bookstore  BP & Other mental Illness   Clinical Research Trials & FDA Drug Approval   Community Support   Contact Us  The Continuum of Mania and Depression   Coping   Criteria    Criteria and Diagnosis  Criteria-World Health Disabilities,  DSMV-IV   Dual Diagnosis  eGroups  Expressions (Poetry, Inspiration, Humor, Art Gallery, Memorials  Family Members   Getting Help for a Loved One who Refuses Treatment  Greeting Cards  History of Mental Illness  Indigo  Job and School  Links  Manage Your Medications  Medications   Medication and Weight Gain    News of the Day  Parent Chat  Pay for Meds  Personal Stories  Self Help  Self Injury  Significant Others  Stigma and Mental Health Law  Storm's Column  Suicide!!!  The Suicide Wall  Table of Contents   Treatments  Treatment Compliance  US Disability  Veteran's Chat  What's New?