Can Seroquel Cause Hypomania?
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Q:  Can Seroquel Cause Hypomania?

Hi Dr. Phelps,

I have read all the information I can find about Seroquel and nothing says it can cause hypomania. I'm sure it does, though. Within an hour of taking it in the evening, I sleep soundly for several hours-no problems there. However, the next day there is an increase in racing thoughts, lack of concentration, etc., until I take the next dose. Without the Seroquel, I never have hypomania several days in a row, but I always do while I am taking Seroquel. This is very frustrating because my doctor says that Seroquel will help this; not worsen it.

Do you know if Seroquel can cause hypomania or similar symptoms?

Thank you very much, Dr. Phelps.


Dear Julie --
I've not seen it, but there is a case report of mania associated with Seroquel (chemical name quetiapine). Here's the reference on that:
Lykouras. So the answer is, you're right, though I'm sure glad I'd just finished looking this issue up on my own, or I could easily have gotten it wrong myself, since I've used a fair bit of Seroquel and never seen anything that looked like a worsening of the manic side of things associated with it. (That's sort of an attempt at an excuse for your doctor; I guess the moral of the story is, never tell a patient "you're wrong" without at least doing a literature search!)

Dr. Phelps

Published October, 2003 


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