Depakote/Lamotrigine Interaction
[Home] [Bipolar News] [Bipolar Disorder] [Medications] [Treatments] [Bipolar Disorder/Job/School] [Disabilities] [Ask the Doctor] [Ask David] [Self-Injury] [Personal Stories] [Graham's Column] [Steven's Column] [Storm's Column] [Columnist Archives] [Suicide] [Community Support] [Family Members] [Expressions] [Greeting Cards] [Books] [Awards] [Links & Rings] [About Us] [Contact Us]


Q:  Depakote/Lamotrigine Interaction

I am confused about your information re: depacote/lamictal interation on the site.

Part of the paragraph from lamotrigine link reads:
...because Depakote can double lamotrigine levels and itself be increased 30% by the lamotrigine; however, then can be used together, one must just be careful with the combination). 

I thought lamictal decreases the efficacy of depacote/and perhaps lowers depacote levels? Perhaps I'm mistaken.

I appreciate your clarification.


Hello Ms. B' --
Well, looks like we're both right in terms of finding statements both ways.  Most sites I just surfed through talk about lamotrigine decreasing Depakote levels; whereas material by Dr. Lori Altshuler, a UCLA expert, states that lamotrigine increases Depakote levels (you have to sift in
here, but you'll find it, if you want to check that reference). 

However, there's a better way than just surfing for references, theoretically, and that's to look at what lamotrigine does to enzymes that metabolize Depakote.  If it lowers them, or their activity, then the medication should increase Depakote levels, and vice versa.  

By that logic, Depakote is listed on one table I consulted as metabolized by the liver enzyme known as CYP - 2C.  Unfortunately I can't find lamotrigine on these lists (they aren't new enough).  If you would like to do some snooping and send me the lamotrigine effects on CYP-2C, that would move things along!  

Thanks for writing. 

Dr. Phelps 

Published September, 2002


Bipolar World   1998, 1999, 2000, 2001, 2002, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014
Allie Bloom, David Schafer, M.Ed. (Blackdog)
Partners:  John Haeckel, Judith (Duff) 
Founder:  Colleen Sullivan

Email Us at Bipolar World


About Us  Add a Link  Advance Directives  Alternative Treatments  Ask the Doctor   Ask Dr. Plyler about Bipolar Disorder   Ask The Doctor/ Topic Archives  Awards  Benny the Bipolar Puppy  Bipolar Chat  Bipolar Children  Bipolar Disorder News  Bipolar Help Contract  Bipolar World Forums  Book Reviews  Bookstore  BP & Other mental Illness   Clinical Research Trials & FDA Drug Approval   Community Support   Contact Us  The Continuum of Mania and Depression   Coping   Criteria    Criteria and Diagnosis  Criteria-World Health Disabilities,  DSMV-IV   Dual Diagnosis  eGroups  Expressions (Poetry, Inspiration, Humor, Art Gallery, Memorials  Family Members   Getting Help for a Loved One who Refuses Treatment  Greeting Cards  History of Mental Illness  Indigo  Job and School  Links  Manage Your Medications  Medications   Medication and Weight Gain    News of the Day  Parent Chat  Pay for Meds  Personal Stories  Self Help  Self Injury  Significant Others  Stigma and Mental Health Law  Storm's Column  Suicide!!!  The Suicide Wall  Table of Contents   Treatments  Treatment Compliance  US Disability  Veteran's Chat  What's New?