Q: Hyperactive Thyroid?
My 17 yr old daughter has been seeing apsychologist and psychiatrist
@ Stanford and was just diagnosed w/ bi-polar II and has rapid-cycling. It
runs in my family, my mother and sister have been diagnosed. Just did a
test for thyroid function the TSH is .06; Hematology: RDW 14.7, MPV 11.3, PLT
morph is large; and blood chemistry: Amylase is 104. Hyperactive thyroid?
She is not thin, just perfect, palpitations, anxious, etc., she has been given
Depakote to treat bp and we are trying to get her into the internist.
Could this possibly be to to a over active thyroid or am I still in denial?
Thank you, any info you could give would be wonderful
Dear Ms. A' --
Good that you're watching so closely and wondering. Here's more, so I can
wonder with you: now that I am very interested in thyroid and bipolar,
I've begun asking all the primary care doc's who refer patients to me for an
evaluation to include a TSH (can't get in without one; I should have done this a
long time ago, as it's nearly always necessary when a patient has mood
symptoms). Now I'm starting to see little blips of
"hyperthyroid", according to the TSH anyway, when people are leaning
in the direction of the manic side symptoms of BPII. Yet they don't have
other manifestations of hyperthyroidism, as you point out your daughter lacked
So, is the hypomania that becomes the basis for a
bipolar diagnosis "just" a thyroid shift? Or is it the other way
around: when a person has hypomania, his/her TSH might shift down toward
"hyperthyroidism" range (less than 0.5 by most labs)? I've not
read anything yet about some kind of "reactive" TSH shifts with
bipolar mood states. And a high TSH is clearly associated with causing
depression, or at least a slowed-down, fatigued, listlessness that responds very
well to TSH and looks like depression (and might cause depression even if
it, itself, wasn't depression per se, because of the impact it would have on
Anyway, you see the point, which is "I don't
know" as far as cause or effect on this association, nor as far as I know
does anybody else. And that's why your asking is such a good thing,
because we all need to keep wondering about this. Sorry it doesn't lead to
some treatment option though (as the high TSH leads to giving thyroid
hormone). Maybe we need to wonder, in this same way, about giving
propylthiouracil (used to treat hyperthyroidism) to "treat" the
hypomania and see what happens. I've never heard of that approach,
though. If the association is more an effect than a cause, i.e. low TSH is
what happens from hypomania, not the reverse, then there would be no sense in
giving PTU, so we really need to know the answer to your question first.
Published May, 2002