Topiramate and Kidney Stones
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Topiramate and Kidney Stones?

Dear Dr. Phelps: I am seriously thinking of switching my medicine for my bipolar symptoms from depakote to topamax because of the weight gain. Can you tell me what the odds are of me getting kidney stones on this medication. My doctor has told me of this risk on the medication. What is your opinion?

Dear Angela --
Risk of stones on topiramate is 1.5% of those who take it -- in the range of 1 person in a hundred.  If you drink a lot of fluid, that reduces the risk.  Here's the reference:

[Med Sci Bull. 1997; 20(1)]

and here's a link to that reference.  I found this by entering "topiramate stones" on Google -- first link that came up.   Handy way to hunt for this kind of thing.

Dr. Phelps


Published October, 2000

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