Cluster headaches and bipolar disorder
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Cluster headaches and bipolar disorder

Q: Is there any relationship between Bipolar II and Cluster Headaches? If so, what, and what treatment would you recommend for both? Thanks - you have a great website by the way!

Dear Chris --
There is clearly a relationship between migraines and bipolar disorder.  Not sure how, but statistically clearly related.  Not sure about Cluster headaches.

However, searching on Pub Med using "cluster headaches bipolar", yields this list:


1: Costa A, Leston JA, Cavallini A, Nappi G. Related Articles
Cluster headache and periodic affective illness: common chronobiological features.

Funct Neurol. 1998 Jul-Sep;13(3):263-72. Review.
PMID: 9800155; UI: 99016537

2: Marchesi C, De Ferri A, Petrolini N, Govi A, Manzoni GC, Coiro V, De Risio C. Related Articles
Prevalence of migraine and muscle tension headache in depressive disorders.

J Affect Disord. 1989 Jan-Feb;16(1):33-6.
PMID: 2521648; UI: 89124135

3: Frost RE, Messiha FS. Related Articles
Clinical uses of lithium salts.

Brain Res Bull. 1983 Aug;11(2):219-31. Review.
PMID: 6414655; UI: 84025710

4: Damasio H, Lyon L. Related Articles
Lithium carbonate in the treatment of cluster headaches.

J Neurol. 1980;224(1):1-8.
PMID: 6157794; UI: 81008685
So I'd say somebody else (1 and 4) seems to have observed an association also, and one team reported treating with lithium.

Dr. Phelps

Published November, 2000


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