|Treatment of affective disorder and
obesity with topiramate.
Teter CJ, Early JJ, Gibbs CM.
College of Pharmacy, University of Michigan, Ann Arbor 48109-1065, USA.
OBJECTIVE: To report a case of weight loss and mood stabilization in a
patient being treated with the antiepileptic drug topiramate. CASE
SUMMARY: A 37-year-old obese white woman with affective instability and
obesity was being treated with adjunctive topiramate therapy. The patient
lost 10 kg over 10 weeks of treatment with topiramate and improved
clinically, as evidenced by a reduction in the number of times that she
had to be admitted to a management unit for constant observation, and a
decrease in the number of times that mechanical restraints or medication
interventions were required for aggressive outbursts. Furthermore, the
patient successfully completed two home visits while receiving topiramate
therapy and was out of the hospital on her third home visit at the time of
this writing. DISCUSSION: This case further strengthens previous reports
that topiramate may be useful in treating affective disorders as well as
inducing weight loss in a patient population in which weight gain is
common. The patient discussed in this case report had no acute illnesses
or changes in health status, no changes in diet, and no changes in her
medications that could have accounted for the sudden weight loss. In
addition, the patient's behavior did not improve until topiramate was
added as adjunctive therapy of valproic acid, citalopram, and
chlorpromazine during an adequate trial period. CONCLUSIONS: Controlled
studies need to be performed to evaluate the use of topiramate in the
psychiatric population and, in particular, the benefits of topiramate
therapy in psychiatric patients with an additional diagnosis of obesity.
PMID: 11098338 [PubMed - indexed for MEDLINE]