Wirshing DA, Pierre JM, Eyeler J, Weinbach J, Wirshing WC.
Department of Psychiatry and Biobehavioral Sciences, University of
California at Los Angeles School of Medicine, USA.
BACKGROUND: Weight gain, and its associated complications such as the
development of diabetes, is becoming increasingly recognized as an
important potential side effect of the novel antipsychotic drugs. METHODS:
Two retrospective cases are described in which patients with schizophrenia
developed diabetes while taking the antipsychotic medication risperidone.
RESULTS: Both patients had preexisting risk factors for diabetes and
developed insulin resistance in the context of weight gain. Both cases
necessitated medical intervention and one patient requires ongoing
treatment with insulin. CONCLUSIONS: Although the exact mechanism of
antipsychotic induced diabetes remains obscure, weight gain appears to be
a significant risk factor. Careful monitoring of weight and fasting
glucoses is recommended for any patient taking novel antipsychotic
PMID: 11526997 [PubMed - indexed for MEDLINE]