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World Health Organization Diagnostic Criteria for Bipolar Disorder 

This information is printed here for educational purposes only and there is no intend to infringe on copyright laws

See the World Health Organization Web Site at http://www.who.int

F31 Bipolar Affective Disorder

This disorder is characterized by repeated (i.e. at least two) episodes in which the patient's mood and activity levels are
significantly disturbed, this disturbance consisting on some occasions of an elevation of mood and increased energy and activity
(mania or hypomania), and on others of a lowering of mood and decreased energy and activity (depression). Characteristically,
recovery is usually complete between episodes, and the incidence in the two sexes is more nearly equal than in other mood
disorders. As patients who suffer only from repeated episodes of mania are comparatively rare, and resemble (in their family
history, premorbid personality, age of onset, and long-term prognosis) those who also have at least occasional episodes of
depression, such patients are classified as bipolar. 

Manic episodes usually begin abruptly and last for between 2 weeks and 4-5 months (median duration about 4 months).
Depressions tend to last longer (median length about 6 months), though rarely for more than a year, except in the elderly. Episodes
of both kinds often follow stressful life events or other mental trauma, but the presence of such stress is not essential for the
diagnosis. The first episode may occur at any age from childhood to old age. The frequency of episodes and the pattern of
remissions and relapses are both very variable, though remissions tend to get shorter as time goes on and depressions to become
commoner and longer lasting after middle age. 

Although the original concept of "manic-depressive psychosis" also included patients who suffered only from depression, the term
"manic-depressive disorder or psychosis" is now used mainly as a synonym for bipolar disorder. 

Includes: 
manic-depressive illness, psychosis or reaction 

Excludes: 
bipolar disorder, single manic episode 
cyclothymia 

F31.6 Bipolar Affective Disorder, Current Episode Mixed

The patient has had at least one manic, hypomanic, or mixed affective episode in the past and currently exhibits either a mixture of
a rapid alternation of manic, hypomanic, and depressive symptoms. 

Diagnostic Guidelines 

Although the most typical form of bipolar disorder consists of alternating manic and depressive episodes separated by periods of
normal mood, it is not uncommon for depressive mood to be accompanied for days or weeks on end by overactivity and pressure
of speech, or for a manic mood and grandiosity to be accompanied by agitation and loss of energy and libido. Depressive
symptoms and symptoms of hypomania or mania may also alternate rapidly, from day to day or even from hour to hour. A
diagnosis of mixed bipolar affective disorder should be made only if the two sets of symptoms are both prominent for the greater
part of the current episode of illness, and if that episode has lasted for a least 2 weeks. 

Excludes: 
single mixed affective episode 

F30 Manic Episode

Three degrees of severity are specified here, sharing the common underlying characteristics of elevated mood, and an increase in
the quantity and speed of physical and mental activity. All the subdivisions of this category should be used only for a single manic
episode. If previous or subsequent affective episodes (depressive, manic, or hypomanic), the disorder should be coded under
bipolar affective disorder. 

Includes: 
bipolar disorder, single manic episode 

F30.0 Hypomania

Hypomania is a lesser degree of mania, in which abnormalities of mood and behaviour are too persistent and marked to be
included under cyclothymia but are not accompanied by hallucinations or delusions. There is a persistent mild elevation of mood
(for at least several days on end), increased energy and activity, and usually marked feelings of well-being and both physical and
mental efficiency. Increased sociability, talkativeness, overfamiliarity, increased sexual energy, and a decreased need for sleep are
often present but not to the extent that they lead to severe disruption of work or result in social rejection. Irritability, conceit, and
boorish behaviour may take the place of the more usual euphoric sociability. 

Concentration and attention may be impaired, thus diminishing the ability to settle down to work or to relaxation and leisure, but this
may not prevent the appearance of interests in quite new ventures and activities, or mild over-spending. 

Diagnostic Guidelines 

Several of the features mentioned above, consistent with elevated or changed mood and increased activity, should be present for
at least several days on end, to a degree and with a persistence greater than described for cyclothymia. Considerable interference
with work or social activity is consistent with a diagnosis of hypomania, but if disruption of these is severe or complete, mania
should be diagnosed. 

Differential Diagnosis
Hypomania covers the range of disorders of mood and level of activities between cyclothymia and mania. The increased activity
and restlessness (and often weight loss) must be distinguished from the same symptoms occurring in hyperthyroidism and anorexia
nervosa; early states of "agitated depression", particularly in late middle-age, may bear a superficial resemblance to hypomania of
the irritable variety. Patients with severe obsessional symptoms may be active part of the night completing their domestic cleaning
rituals, but their affect will usually be the opposite of that described here. 

When a short period of hypomania occurs as a prelude to or aftermath of mania, it is usually not worth specifying the hypomania
separately. 


F30.1 Mania Without Psychotic Symptoms

Mood is elevated out of keeping with the individual's circumstances and may vary from carefree joviality to almost uncontrollable
excitement. Elation is accompanied by increased energy, resulting in overactivity, pressure of speech, and a decreased need for
sleep. Normal social inhibitions are lost, attention cannot be sustained, and there is often marked distractability. Self-esteem is
inflated, and grandiose or over-optimistic ideas are freely expressed. 

Perceptual disorders may occur, such as the appreciation of colours as especially vivid (and usually beautiful), a preoccupation
with fine details of surfaces or textures, and subjective hyperacusis. The individual may embark on extravagant and impractical
schemes, spend money recklessly, or become aggressive, amorous, or facetious in inappropriate circumstances. In some manic
episodes the mood is irritable and suspicious rather than elated. The first attack occurs most commonly between the ages of 15
and 30 years, but may occur at any age from late childhood to the seventh or eighth decade. 

Diagnostic Guidelines 

The episode should last for at least 1 week and should be severe enough to disrupt ordinary work and social activities more or less
completely. The mood change should be accompanied by increased energy and several of the symptoms referred to above
(particularly pressure of speech, decreased need for sleep, grandiosity, and excessive optimism). 

F30.2 Mania With Psychotic Symptoms

The clinical picture is that of a more severe form of mania as described above. Inflated self-esteem and grandiose ideas may
develop into delusions, and irritability and suspiciousness into delusions of persecution. In severe cases, grandiose or religious
delusions of identity or role may be prominent, and flight of ideas and pressure of speech may result in the individual becoming
incomprehensible. Severe and sustained physical activity and excitement may result in aggression or violence, and neglect of
eating, drinking, and personal hygiene may result in dangerous states of dehydration and self-neglect. If required, delusions or
hallucinations can be specified as congruent or incongruent with the mood. "Incongruent" should be taken as including affectively
neutral delusions and hallucinations; for example, delusions of reference with no guilty or accusatory content, or voices speaking to
the individual about events that have no special emotional significance. 

Differential Diagnosis
One of the commonest problems is differentiation of this disorder from schizophrenia, particularly if the stages of development
through hypomania have been missed and the patient is seen only at the height of the illness when widespread delusions,
incomprehensible speech, and violent excitement may obscure the basic disturbance of affect. Patients with mania that is
responding to neuroleptic medication may present a similar diagnostic problem at the stage when they have returned to normal
levels of physical and mental activity but still have delusions or hallucinations. Occasional hallucinations or delusions as specified
for schizophrenia may also be classed as mood-incongruent, but if these symptoms are prominent and persistent, the diagnosis of
schizoaffective disorder is more likely to be appropriate. 

Includes: 
manic stupor 


F32 Depressive Episode

In typical depressive episodes of all three varieties described below (mild, moderate, and severe), the individual usually suffers
from depressed mood, loss of interest and enjoyment, and reduced energy leading to increased fatiguability and diminished activity.
Marked tiredness after only slight effort is common. Other common symptoms are: 

(a) reduced concentration and attention; 
(b) reduced self-esteem and self-confidence; 
(c) ideas of guilt and unworthiness (even in a mild type of episode); 
(d) bleak and pessimistic views of the future; 
(e) ideas or acts of self-harm or suicide; 
(f) disturbed sleep; 
(g) diminished appetite. 

The lowered mood varies little from day to day, and is often unresponsive to circumstances, yet may show a characteristic diurnal
variation as the day goes on. As with manic episodes, the clinical presentation shows marked individual variations, and atypical
presentations are particularly common in adolescence. In some cases, anxiety, distress, and motor agitation may be more
prominent at times than the depression, and the mood change may also be masked by added features such as irritability, excessive
consumption of alcohol, histrionic behaviour, and exacerbation of pre-existing phobic or obsessional symptoms, or by
hypochondriacal preoccupations. For depressive episodes of all three grades of severity, a duration of at least 2 weeks is usually
required for diagnosis, but shorter periods may be reasonable if symptoms are unusually severe and of rapid onset. 

Some of the above symptoms may be marked and develop characteristic features that are widely regarded as having special
clinical significance. The most typical examples of these "somatic" symptoms are: loss of interest or pleasure in activities that are
normally enjoyable; lack of emotional reactivity to normally pleasurable surroundings and events; waking in the morning 2 hours or
more before the usual time; depression worse in the morning; objective evidence of definite psychomotor retardation or agitation
(remarked on or reported by other people); marked loss of appetite; weight loss (often defined as 5% or more of body weight in
the past month); marked loss of libido. Usually, this somatic syndrome is not regarded as present unless about four of these
symptoms are definitely present. 

The categories of mild, moderate and severe depressive episodes described in more detail below should be used only for a single
(first) depressive episode. Further depressive episodes should be classified under one of the subdivisions of recurrent depressive
disorder. 

These grades of severity are specified to cover a wide range of clinical states that are encountered in different types of
psychiatric practice. Individuals with mild depressive episodes are common in primary care and general medical settings, whereas
psychiatric inpatient units deal largely with patients suffering from the severe grades. 

Acts of self-harm associated with mood (affective) disorders, most commonly self-poisoning by prescribed medication, should be
recorded by means of an additional code from Chapter XX of ICD-10 (X60-X84). These codes do not involve differentiation
between attempted suicide and "parasuicide", since both are included in the general category of self-harm. 

Differentiation between mild, moderate, and severe depressive episodes rests upon a complicated clinical judgement that involves
the number, type, and severity of symptoms present. The extent of ordinary social and work activities is often a useful general
guide to the likely degree of severity of the episode, but individual, social, and cultural influences that disrupt a smooth relationship
between severity of symptoms and social performance are sufficiently common and powerful to make it unwise to include social
performance amongst the essential criteria of severity. 

The presence of dementia or mental retardation does not rule out the diagnosis of a treatable depressive episode, but
communication difficulties are likely to make it necessary to rely more than usual for the diagnosis upon objectively observed
somatic symptoms, such as psychomotor retardation, loss of appetite and weight, and sleep disturbance. 

Includes: 
single episodes of depression (without psychotic symptoms), psychogenic depression or reactive depression) 

F32.0 Mild Depressive Episode

Diagnostic Guidelines 

Depressed mood, loss of interest and enjoyment, and increased fatiguability are usually regarded as the most typical symptoms of
depression, and at least two of these, plus at least two of the other symptoms described above should usually be present for a
definite diagnosis. None of the symptoms should be present to an intense degree. Minimum duration of the whole episode is about
2 weeks. 

An individual with a mild depressive episode is usually distressed by the symptoms and has some difficulty in continuing with
ordinary work and social activities, but will probably not cease to function completely. 

A fifth character may be used to specify the presence of the somatic syndrome: 

F32.00 Without somatic symptoms
The criteria for mild depressive episode are fulfilled, and there are few or none of the somatic symptoms present. 

F32.01 With somatic symptoms
The criteria for mild depressive episode are fulfilled, and four or more of the somatic symptoms are also present. (If only two or
three somatic symptoms are present but they are unusually severe, use of this category may be justified.) 

F32.1 Moderate Depressive Episode

Diagnostic Guidelines 

At least two of the three most typical symptoms noted for mild depressive episode should be present, plus at least three (and
preferably four) of the other symptoms. Several symptoms are likely to be present to a marked degree, but this is not essential if a
particularly wide variety of symptoms is present overall. Minimum duration of the whole episode is about 2 weeks. 

An individual with a moderately severe depressive episode will usually have considerable difficulty in continuing with social, work
or domestic activities. 

A fifth character may be used to specify the occurrence of somatic symptoms: 

F32.10 Without somatic symptoms
The criteria for moderate depressive episode are fulfilled, and few if any of the somatic symptoms are present. 

F32.11 With somatic symptoms
The criteria for moderate depressive episode are fulfilled, and four or more or the somatic symptoms are present. (If only two or
three somatic symptoms are present but they are unusually severe, use of this category may be justified.) 

F32.2 Severe Depressive Episode Without Psychotic Symptoms

In a severe depressive episode, the sufferer usually shows considerable distress or agitation, unless retardation is a marked
feature. Loss of self-esteem or feelings of uselessness or guilt are likely to be prominent, and suicide is a distinct danger in
particularly severe cases. It is presumed here that the somatic syndrome will almost always be present in a severe depressive
episode. 

Diagnostic Guidelines 

All three of the typical symptoms noted for mild and moderate depressive episodes should be present, plus at least four other
symptoms, some of which should be of severe intensity. However, if important symptoms such as agitation or retardation are
marked, the patient may be unwilling or unable to describe many symptoms in detail. An overall grading of severe episode may still
be justified in such instances. The depressive episode should usually last at least 2 weeks, but if the symptoms are particularly
severe and of very rapid onset, it may be justified to make this diagnosis after less than 2 weeks. 

During a severe depressive episode it is very unlikely that the sufferer will be able to continue with social, work, or domestic
activities, except to a very limited extent. 

This category should be used only for single episodes of severe depression without psychotic symptoms; for further episodes, a
subcategory of recurrent depressive disorder should be used. 

Includes: 
single episodes of agitated depression 
melancholia or vital depression without psychotic symptoms 

F32.3 Severe Depressive Episode With Psychotic Symptoms

Diagnostic Guidelines 

A severe depressive episode which meets the criteria given for severe depressive episode without psychotic symptoms and in
which delusions, hallucinations, or depressive stupor are present. The delusions usually involve ideas of sin, poverty, or imminent
disasters, responsibility for which may be assumed by the patient. Auditory or olfactory hallucinations are usually of defamatory or
accusatory voices or of rotting filth or decomposing flesh. Severe psychomotor retardation may progress to stupor. If required,
delusions or hallucinations may be specified as mood-congruent or mood-incongruent. 

Differential Diagnosis
Depressive stupor must be differentiated from catatonic schizophrenia, from dissociative stupor, and from organic forms of stupor.
This category should be used only for single episodes of severe depression with psychotic symptoms; for further episodes a
subcategory of recurrent depressive disorder should be used. 

Includes: 
single episodes of major depression with psychotic symptoms, psychotic depression, psychogenic depressive psychosis,
reactive depressive psychosis 

-Bipolar World thanks Internet Mental Health for above text

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